Year: 2025
Type: article
Abstract: Constipation is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. The present study aims to evaluate the acute toxicity and efficacy of selected bioactive compounds for the treatment of constipation. Acute toxicity was assessed using standardized in vivo models to determinethe safety profile of the bioactive compounds. The therapeutic efficacy was evaluated through pharmacodynamic and biochemical analyses, focusing on bowel motility, stool frequency, and intestinal microbiota modulation. Preliminary findings suggest that the tested compounds exhibit favorable safety margins and potent laxative effects, potentially offering a novel approach for constipation management. Further clinical studies are required to validate their long-term safety and effectiveness.
Institution: Tashkent Medical Academy
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409304872