Year: 2025
Type: article
Abstract: The present study focuses on the formulation and evaluation of a topical drug delivery system for capsaicin in the form of an emulgel. The emulgel was developed using Carbopol 974 as a gelling agent, Tween 20 as an emulsifier, and propylene glycol as a penetration enhancer, with methyl paraben and propyl paraben serving as preservatives. Capsaicin, a hydrophobic drug, was effectively incorporated into the formulation. The prepared emulgels were evaluated for their physical appearance, pH, viscosity, spreadability, in-vitro drug release, and drug content. The formulations demonstrated good stability, homogeneity, and were free from irritation, redness, itching, or allergic reactions. In-vitro drug release studies revealed a maximum drug release of 90.51% over 6 hours. Among the developed formulations, batch F1 exhibited the best drug release profile and was selected as the optimized formulation. These findings indicate that the formulated capsaicin emulgel is a promising candidate for topical drug delivery.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4409394504