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Levodopa and nutrition support: A case report of Parkinsonism‐hyperpyrexia syndrome

Year: 2025

Type: article

Abstract: Levodopa is competitively inhibited by amino acids for absorption across the intestinal wall and blood-brain barrier. An acute withdrawal of levodopa increases the risk of Parkinsonism-hyperpyrexia syndrome, a life-threatening condition characterized by muscular rigidity, mental status changes, hyperthermia, and autonomic instability. This report discusses the case of a patient with Parkinson's disease who was critically ill who developed Parkinsonism-hyperpyrexia syndrome while receiving enteral and parenteral nutrition support. Clinicians should be aware of this potential drug-nutrient interaction when prescribing nutrition support to patients taking levodopa.

Source: Nutrition in Clinical Practice

DOI: 10.1002/ncp.11297

Authors: Ryan Burslem, Liz Ramos, Chou Chou, Carolina Szlufman, Jane Ziegler

Institutions: NewYork–Presbyterian Hospital, Weill Cornell Medical Center, Weill Cornell Medicine, Rutgers, The State University of New Jersey

Language: English

Topic: Clinical Nutrition and Gastroenterology

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4409401767

FWCI: 1.108

Cites: 20

Cited by: 2

Related to: 10