Year: 2025
Type: article
Abstract: The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIP n ) signaling is a critical regulator of these processes and other biological activities, though its precise impact on cytoskeletal dynamics has yet to be systematically investigated. This review explores the complex interplay between PIP n signaling and the cytoskeleton, detailing how PIP n modulates the dynamics of actin, intermediate filaments, and microtubules to shape cellular behavior. Dysregulation of PIP n signaling is implicated in various diseases, including cancer, highlighting promising therapeutic opportunities through targeted modulation of these pathways. Future research should aim to elucidate the intricate molecular interactions and broader cellular responses to PIP n signaling perturbations, particularly in disease contexts, to devise effective strategies for restoring cytoskeletal integrity.
Source: Cell Death and Disease
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,990
Funders: U.S. Department of Defense, Breast Cancer Research Foundation, Natural Science Foundation of Shenzhen City, National Natural Science Foundation of China, Capital Medical University, Chinese Academy of Medical Sciences, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences
Awards: G1500470957, G1731713565, G2040153736, G3060711190, TARGETING A NOVEL LIPID KINASE COMPLEX THAT REGULATES MUTANT P53 STABILITY IN TRIPLE-NEGATIVE BREAST CANCER, THERAPEUTIC TARGETING OF A LIPID KINASE REGULATOR OF MUTANT P53 IN BREAST CANCER, G3809024919, G4052487769, G4119534169, TARGETING A LIPID KINASE REGULATOR OF NUCLEAR AKT IN BREAST CANCER, TARGETING A LIPID KINASE REGULATOR OF NUCLEAR AKT IN BREAST CANCER, G553799318, G5655888647, G5850682332, G6297567305, G6701450361, G6915834584, TARGETING A NOVEL LIPID KINASE COMPLEX THAT REGULATES MUTANT P53 STABILITY IN TRIPLE-NEGATIVE BREAST CANCER, G9000042692
OpenAlex ID: W4409411684