ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1
Year: 2025
Type: article
Source: Cell
Institutions: Brigham and Women's Hospital, Harvard University, University of Kentucky, Lexington VA Health Care System, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Kobe University, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Helmholtz Munich
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, American Heart Association, California Department of Fish and Game, Elon University, CRC Health Group, Engineering Research Centers, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, National Institutes of Health, Horizon 2020 Framework Programme, European Research Council, Japan Society for the Promotion of Science, Japan Science and Technology Agency, Horizon 2020, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, Moonshot Research and Development Program
Awards: G1025412192, G1515315393, Food-inspired Cardiovascular Therapeutics, G1946894139, G2130236945, G2810377833, G2901363141, G3235113436, G3589119, G3977787679, G4248395557, G4839536358, G4916980965, Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension, Regulation of pulmonary vascular cell redox state by L-2-hydroxyglutarate, G5333538353, G5343035205, FERROPath - Ferroptose als grundlegender Pathomechanismus bei Ischämie/Reperfusionsschäden im Gewebe, TP2: Mausmodelle und Ferroptose-Inhibitoren, TP5: Ferroptose-Beitrag zur Abstoßung von Lungentransplantaten, G5519076145, G5970495531, G6793355958, Systems and Network Medicine Approach to Cardiovascular Complications of SARS-CoV-2 and their Personalized Treatment, G716077576, Mechanism of Ferroptosis resistance in pancreatic ductal adenocarcinoma cells by Rif, G7652281099, G7796086325, Role of lactate transporters in pulmonary fibrosis, L-2-Hydroxyglutarate and Metabolic Remodeling in Hypoxia, Branched-chain Keto-acids and Aerobic Glycolysis in Vascular Smooth Muscle Cells, Mechanisms and Physiology of COPI Transport
OpenAlex ID: W4409412632