Work

Double filtration plasmapheresis in autoimmune gastritis with subacute combined degeneration of the spinal cord: A case report

Year: 2025

Type: article

Abstract: Autoimmune gastritis (AIG) is characterized by the destruction of gastric parietal cells, leading to vitamin B12 deficiency and potentially causing subacute combined degeneration of the spinal cord (SCD). We present a case of a 61-year-old male with AIG who developed SCD and underwent three sessions of double filtration plasmapheresis (DFPP), resulting in significant reduction of autoantibody titers and improvement in neurological symptoms. DFPP demonstrated efficacy in treating AIG complicated by SCD, offering potentially faster clinical response than conventional therapies by rapidly reducing autoantibody levels. This case underscores the importance of early diagnosis and intervention in preventing irreversible neurological damage, suggesting DFPP as a promising adjunctive treatment for AIG with SCD and warranting further investigation into its mechanisms and applications in autoimmune diseases.

Source: Journal of Neuroimmunology

DOI: 10.1016/j.jneuroim.2025.578618

Authors: Qiuju Li, Bin Liu, Yangtai Guan, Yuhui Wang

Institutions: Shanghai Jiao Tong University, Renji Hospital, Punan Hospital

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360