The effect of caffeine on alpha activity in the cerebral cortex of rats in different models of depression
Year: 2025
Type: article
Abstract: The aim of the study is to determine changes in the power spectral density of the alpha-like rhythm of the cerebral cortex in models of contagious depression and chronic unpredictable stress, as well as to study the effect of caffeine on these indicators. Materials and methods. The study was conducted on white sexually mature male rats weighing 230–300 grams. Six groups were formed according to the type of depression and caffeine consumption. The electroencephalographic method was used, and the power spectral density analysis in the alpha range was performed to assess the depressive-like state and the effect of caffeine. The power spectral density of alpha activity (8–12 Hz) was assessed in the cortical zones of male rats: Fp1, Fp2, F3, F4, P3, P4, O1, O2. Results. The assessment of the power spectral density of activity in the 8–12 Hz range in the Fp1 and Fp2 points showed a statistically significant interaction between the type of depression and the effect of caffeine. In the Fp2 area, the effect of depression was more noticeable. In both types of depression, a significant increase in the power spectral density in the 8–12 Hz range was observed in the F3 and F4 areas. The administration of caffeine reduced these indicators, but did not ultimately reduce the effects of depression. In the P3 and P4 points, depression has no significant impact on the power spectral density, while caffeine reduces the power of the alpha range in both hemispheres. Caffeine reduced the power spectral density in all groups in the occipital areas (points O1 and O2). In contrast, in animals with depressive states, the effect of caffeine was only partial. Conclusions. Depression of different genesis affects different parts of the brain differently. Alpha spectral power density increases in frontal and occipital regions and decreases in the prefrontal cortex. Caffeine significantly reduces power spectral density in occipital, frontal, and parietal areas
Source: ScienceRise Biological Science
Authors: Valeriia Mizin, Olena Severynovska
Institution: Oles Honchar Dnipro National University
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $53
OpenAlex ID: W4409433468