Work

A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy

Year: 2025

Type: article

Abstract: Introduction: Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy. Case Presentation: A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage. Conclusion: This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.

Source: IJU Case Reports

DOI: 10.1002/iju5.70031

Authors: Rintaro Yoshitake, Syunsuke Taguchi, Yoshimasa Harada

Institutions: Hikone Municipal Hospital, Nagahama Red Cross Hospital

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,960