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Type 1 Diabetes TrialNet: Leading the Charge in Disease Prediction, Prevention, and Immunotherapeutic Mechanistic Understanding

Year: 2025
Type: review
Abstract: Established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in 2001, Type 1 Diabetes TrialNet (TrialNet) is an international consortium of clinical research centers that studies the development of type 1 diabetes and performs clinical studies aimed at delaying or preventing the disease. In recognition of NIDDK's 75th anniversary, this review will summarize the major findings, accomplishments, and future opportunities of its long-running program TrialNet. More than 20 intervention, observational, and mechanism-directed clinical studies have been conducted in collaboration with thousands of people living with type 1 diabetes and their families. New and repurposed immunotherapies have been successful in stages 2 and 3 of type 1 diabetes, contributing to the U.S. Food and Drug Administration approval of the first disease-modifying therapy to delay the onset of type 1 diabetes. Mechanistic findings continue to drive ongoing and future trial designs including novel combination therapies. TrialNet has several ongoing trials, with several for early stages of type 1 diabetes in development. There are new initiatives within TrialNet for community engagement, increasing clinical trial representation, personalizing treatments, and training the next generation of translational investigators.
DOI: 10.2337/dc24-2908
Authors: Laura M. Jacobsen, Jamie L. Felton, Brandon M. Nathan, Cate Speake, Jeffrey Krischer, Kevan C. Herold
Institutions: University of Florida Health, University of Florida, Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, University of Minnesota, Benaroya Research Institute, University of South Florida, Yale University
Language: English
Subfield: Genetics
Open Access status: bronze
Funders: Sanofi, Insulet Corporation, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: TrialNet: University of Florida Clinical Center and Network, Type 1 Diabetes-A Proposal for Prevention & Intervention, G2291309925, Type 1 Diabetes TrialNet Clinical Centers - Kansas City, Prediction and Prevention of Type 1 Diabetes (TrialNet), Type 1 Diabetes TrialNet: Clinical Center at Berrie Center, Columbia University, Type 1 Diabetes TrialNet: Toronto Clinical Center, G5290762218, NIDDK Type 1 Diabetes TrialNet Data Coordinating Center, TrialNet at Stanford University, Type 1 Diabetes TrialNet: Clinical Centers (U01), Type 1 diabetes TrialNet Center at Yale University, TrialNet: Diabetes Type 1 Prevention, Type 1 Diabetes TrialNet at Indiana University Clinical Center, An Atlanta TrialNet Center: Building a Pathway to 70 Clinical Trial Subjects per Year, Data Coordinating Center for Type 1 Diabetes TrialNet, Type 1 Diabetes TrialNet Clinical Network Hub, Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs), Yale Diabetes Research Center
OpenAlex ID: W4409781978
FWCI: 2.875
Cites: 77
Cited by: 19
Related to: 10