Work

The new N2-phenyl-N4-5-(dimethylphosphinyl)-6-quinoxalinamine pyrimidine-2,4-diamine derivatives as EGFR inhibitors to overcome C797S-mediated resistance

Year: 2025

Type: article

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2025.118224

Authors: Jiadai Liu, Jiaqi Qiu, Chunlong Wang, Haoran Nie, Mengxuan Wang, Shuai Zhang, Fangyi Jia, Xianping Dai, Baijiao An

Institutions: Binzhou Medical University, China Pharmaceutical University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Key Technology Research and Development Program of Shandong

Awards: G4379819113, G4774070475, G5151345445

OpenAlex ID: W4410101147

FWCI: 0.6

Cites: 18

Cited by: 1

Related to: 10