Work

Rational Design of Dual Degraders by Incorporating Molecular Glue Structural Features into PROTAC Degraders

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00443

Authors: Bowen Zhang, Shan Gao, Tingting Wu, Yan Ma, Senbiao Fang, Mengyan Rong, Wenrui Jia, Sai Zhang, Hui Hou, Xiao Wang, Siqi Zhang, Chong Qin

Institutions: Ocean University of China, Marine Biomedical Research Institute of Qingdao

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Ocean University of China, Qingdao National Laboratory for Marine Science and Technology, Key Technology Research and Development Program of Shandong, National Outstanding Youth Science Fund Project of National Natural Science Foundation of China, Natural Science Fund for Distinguished Young Scholars of Shandong Province, National Key Research and Development Program of China

Awards: G2179247509, G2747180576, G6795592452, G7209871012

OpenAlex ID: W4410243796

FWCI: 3.753

Cites: 45

Cited by: 17

Related to: 10