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Sarcoidosis Presenting as a Giant Pulmonary Bulla With Concurrent COVID-19 Infection

Year: 2025

Type: article

Abstract: Sarcoidosis is a systemic granulomatous disease that predominantly affects the lungs. However, its presentation as a giant pulmonary bulla is exceptionally rare. Its association with COVID-19 has raised new concerns regarding disease exacerbation and misdiagnosis. We report a case of a 38-year-old man who developed a large left lower lobe bulla in the context of recent COVID-19 infection. Initial misinterpretation of the bulla as loculated pneumothorax nearly led to an unnecessary chest tube placement. A subsequent thoracotomy with lobectomy revealed nonnecrotizing granulomas, confirming sarcoidosis. The patient showed spontaneous remission without requiring treatment. This case highlights the importance of multidisciplinary discussions in atypical lung presentations to prevent mismanagement.

Source: Journal of Investigative Medicine High Impact Case Reports

DOI: 10.1177/23247096251340738

Authors: Sathish Krishnan, Anam Naumaan, Venu Pararath Gopalakrishnan

Institutions: Community Health Network, University of Massachusetts Chan Medical School

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200