Assessment of Querectin Influence on Multiple Physiological, Biochemical and Immunological Parameters in Diabetic Rats
Year: 2025
Type: article
Abstract: Background: Diabetes is a worldwide disease threatens a large number of the human population due to their complication which extended to almost all body organs. Recently querectin were studied to their pharmaceutical activities. Methods: Therefore this paper studied the effect of querectin on multiple physiological, biochemical and immunological markers for diabetic rats supplemented with querectin 150 m/k orally for 30 days. Result: The result revealed that lipid profile improved in treated rats in-compared to untreated groups as cholesterol result was 176±3.09 mg/dl versus 210±5.2 mg/dl in the untreated group, triglyceride 150.3±2.85 mg/dl versus 176±4.30 mg/dl, high density lipoprotein result was 37.42±2.9 mg/dl versus 24.43±3.2 mg/dl, low density lipoprotein 109.59±6.85 mg/dl versus 151.29±5.70 mg/dl and very low density lipoprotein (30.45±2.90 versus 35.20±3.52) mg/dl in P value ≤0.01. In addition, glucose level was gradually reduced in treated group against non-treated one (200.43±1.96, 320±2.85) mg/dl. Urea and creatinine level was restored in quarectin treated rats (29.50±2.43, 0.96±0.06) mg/dl respectively in compared to diabetic untreated rats (37.54±3.53, 1.6±0.05) mg/dl. Immunological parameters including TNF-α, IL-1, IL-6 and C-reactive protein (CRP) showed a significant reduction in comparison to untreated rats (2.48±0.39, 4.70±1.22) for TNF-α, (4.38±1.59, 7.69±1.32) for IL-1, (3.24±0.12, 5.05±1.42) and (4.60±0.53, 5.05±0.54) for CRP. Similar results was shown in lactate dehydrogenase (157.54±3.65, 17.54±3.32) for treated and non treated rats respectively, anti-oxidant parameters were measured and te results were catalase significantly restored in treated group (10.30±2.76, 13.70±2.63), super oxide dismutase (7.13±2.67, 9.94±2.94) and malondialhdeyde (2.90±0.39, 4.89±0.48) in a P value ≤0.05.
Authors: Sara Saeb Rasheed, Rawnaq Z. Fadhil, Salah M.M. AL-Chalabi, Rawaa Adnan Khalaf, Ferial A. Al Mahdawi, Ahmed Flayyih Hasan
Institutions: Nahrain University, Al-Farabi University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Al-Nahrain University
OpenAlex ID: W4410312281