Analysis of Antibiotic Resistance Among KPC-3 Positive Pseudomonas aeruginosa Strains Isolated from Intensive Care Unit Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: are frequent causes of life-threatening hospitalacquired infections (3).The Brazilian Health Surveillance Agency reports that 42.9% of P. aeruginosa isolates causing catheter-related bloodstream infections in intensive care units (ICUs) exhibit carbapenem resistance (3, 4).The high resistance rates in P. aeruginosa are attributed to multiple mechanisms, including overexpression of resistance-nodulation-division (RND) efflux systems, porin (OprD) loss, AmpC β-lactamase absence, and carbapenemase production (4).These adaptations, coupled with horizontal gene transfer through plasmids, significantly enhance its resistance profile and complicate treatment (5).As a major nosocomial pathogen, P. aeruginosa is associated with high morbidity and mortality rates, particularly in ICU settings.Its remarkable adaptability and ability to survive in diverse environments underscore its ABSTRACTThe increase in antibiotic resistance among microorganisms is an issue of utmost importance.Specifically, the resistance to carbapenem and extended-spectrum β-lactam antibiotics in gram-negative bacteria has had a considerable impact on patient morbidity and mortality rates.This research is centered around the examination of severe infections caused by Pseudomonas aeruginosa and KPC-3 in patients who have been admitted to intensive care units.P. aeruginosa strains were collected from the intensive care units of Van Training and Research Hospital.In order to conduct a thorough microbiological analysis of these strains, various methods including culture, biochemical tests, antibiogram tests, and polymerase chain reaction (PCR) were employed.A total of 126 carbapenem-resistant P. aeruginosa strains were extracted from patients within intensive care units.Among these isolates, 17 were identified as being both multidrug -resistant and positive for KPC-3.Interestingly, all of the identified strains exhibited sensitivity to Amikacin, Piperacillin, Piperacillin/Tazobactam, Gentamicin, Colistin, Fosfomycin and Tigecycline.The identification of KPC-3 positive P. aeruginosa strains among patients in our hospital highlights a concerning issue.It has been observed that this presence increases the risk of both mortality and morbidity in affected patients.Consequently, it has been deemed crucial to address this matter in terms of hospital surveillance practices and the implementation of strategies to combat antibiotic resistance.
Source: Eastern Journal Of Medicine
Authors: OMER AKGUL, Gülhan Bora
Institution: Van Yüzüncü Yıl Üniversitesi
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410568340