Work

Levels of systemic inflammatory biomarkers in patients with atrial fibrillation: Analysis based on a comparison of propensity scores

Year: 2025

Type: article

Abstract: Objective: to compare the levels of biomarkers of systemic inflammation between groups of patients with paroxysmal and persistent forms of atrial fibrillation (AF). Material and methods. The study included 232 patients diagnosed with AF who underwent the primary procedure of pulmonary vein ablation. The average age was 62 (54;67) years. Patients were divided into two groups: with paroxysmal and persistent forms of AF. Results. As a result of the analysis of the levels of inflammatory markers, no statistically significant differences were found between the groups. For systemic inflammatory response index, 0.8 (0.6; 1.1) vs 0.9 (0.7; 1.1); p=0.077; for systemic inflammation index 361 (276; 509) vs 373 (294; 551); p=0.505; for aggregate inflammation systemic index 170 (122; 255) vs 197 (139; 259); p=0.150; for neutrophils lymphocytes ratio 1.6 (1.3; 2.2) vs 1.8(1.3; 2.3); p=0.428; for platelets lymphocytes ratio 122 (86; 132) vs 107 (91; 130); p= 0.576; for monocytes lymphocytes ratio 0.228 (0.177; 0.291) vs 0.241 (0.2200; 0.301); p=0.262. After statistical correction for the initial clinical characteristics, no differences were also obtained. According to the ROC analysis, no statistically significant threshold values of the levels of the studied markers were found for each form of AF. Conclusion. In this study, there was no difference in the level of "new" biomarkers of systemic inflammation between patients with paroxysmal and persistent forms of AF. Currently, data on the existence of an association between the levels of biomarkers of systemic inflammation and various forms of AF are contradictory, further research in this direction is required.

Source: Saratov Journal of Medical Scientific Research

DOI: 10.15275/ssmj2101037