Gut-brain communication: Functional anatomy of vagal afferents
Year: 2025
Type: review
Abstract: There is increasing interest in interoceptive mechanisms as a key player in mental health. The vagus nerve is an important pathway of communication between the body and the brain, and recent advances in neurobiological techniques have enabled the identification of function-specific populations of vagal sensory neurons. Here we briefly review this progress, focusing on vagal innervation of the gut and its involvement in ingestive behavior, metabolic regulation, and immune defense. While we have learned much about the organization of the peripheral interface of the sensory vagal system, dissemination of information within the brain is still poorly understood. Yet, a deeper understanding of the brain's integration of vagal input will be necessary for the informed development of neuromodulation therapies for various diseases linked to interoception.
Source: Current Opinion in Neurobiology
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,320
Awards: Neural circuits coordinating protein intake: Role of FGF21, G4546073948, FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction, Integration of Lepr circuits for thermoregulation and energy status, Neural mechanisms controlling food intake and body weight after bariatric surgery, Metabolic Changes: Connecting temperature sensing neurons to sympathetic adipose tissue stimulation
OpenAlex ID: W4410944880