Prognostic Value of a Novel Lactate-shock Index for 28-day Mortality in Adult Sepsis Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Abs tractAim: Early and accurate diagnosis of sepsis allows for the timely initiation of appropriate treatment, which can improve clinical outcomes.Studies have shown that the shock index (SI) and high lactate levels are successful in predicting mortality and adverse outcomes in various clinical situations.However, the variability in lactate levels due to various factors limits its usability when used alone.Considering these limitations, we aimed to evaluate the performance of a combined lactate SI (LSI) in predicting 28-day mortality in patients with sepsis.Methods: Patients aged 18 and over who were diagnosed with sepsis between 15.02.2023 and 15.12.2023 and presented to the emergency department (ED) were included in the study.Sepsis diagnosis was evaluated according to the criteria in the sepsis-3 guidelines.Data collection for patients presenting to the ED with suspected sepsis included demographic findings such as age and gender.Glasgow coma scale score; vital signs including systolic blood pressure (mmHg), diastolic blood pressure (mmHg), heart rate (bpm), body temperature (°C), and respiratory rate (breaths/min).The SI, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio, and LSI values were calculated and recorded in the data collection form.Results: The study included a total of 77 patients, with 28-day mortality occurring in 31 patients (40.3%).Multivariate logistic regression analysis identified SI [Odds ratio (OR), 9.623, p=0.023] and LSI (OR: 1.333, p=0.029) as independent prognostic indicators of 28-day mortality.In the receiver operating characteristic analysis, LSI [area under the curve (AUC): 0.710] outperformed both SI (AUC: 0.690) and lactate (AUC: 0.681).Conclusion: This study demonstrates that LSI is an independent predictor of 28-day mortality in patients with sepsis.Lactate shock index showed better performance than both lactate and SI in predicting 28-day mortality.
Source: Medical Bulletin of Haseki
Authors: Ibrahim Caltekin, Adem Koksal, Ali Aygun, Mehmet Seyfettin Saribas, Mesut Tomakin
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411041316