Modern Treatment of Inflammatory Pulmonary Pathology: Theoretical Justification and Implementation of the Extracorporeal Blood Hyperthermia Apparatus into Medical Practice
Year: 2025
Type: article
Abstract: For the first time in Ukraine, our team successfully applied extracorporeal blood hyperthermia (EBH) within a closed-loop circuit to manage inflammatory conditions of the lungs and pleura. Controlled warming of autologous blood to 38°C and its subsequent reinfusion produced rapid, clinically significant reductions in exudative pleurisy, pleural empyema, and paracancerous inflammatory lesions. Earlier, EBH had been incorporated into U.S. military field protocols between 2003 and 2007, and it is now formally included in therapeutic guidelines across the United States, Canada, New Zealand, multiple European nations, and several African healthcare systems. Our findings corroborate international data showing that mild systemic hyperthermia enhances phagocytic activity, improves microcirculation within the pleural cavity, and accelerates resorption of inflammatory exudate while maintaining a favorable safety profile. No severe adverse events or hemodynamic instabilities were observed during or after the procedures in our cohort. Beyond its direct anti-inflammatory impact, EBH may potentiate antibiotic penetration into pleural tissues, offering a valuable adjunct in the era of rising antimicrobial resistance. Future multicenter trials with larger patient populations and comparative cost-effectiveness analyses are warranted to refine treatment parameters and confirm long-term benefits of this promising modality.
Source: SSP Modern Pharmacy and Medicine
Authors: Oleksandr Nevzghoda, Anatolii Nevzghoda
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411046010