Work

The association between carbon monoxide and blood pressure changes mediated by lipid metabolites in children: from a prospective and nested case-control study

Year: 2025

Type: article

Abstract: Background. This study aims to investigate the association between carbon monoxide (CO) and blood pressure (BP), which may be mediated by lipid metabolites. Methods. This study utilized data from the Health Cohort Study of Children and Adolescents in Chongqing, China. The absolute quantification of lipid profiling was performed using ultra-high-performance liquid chromatography tandem mass spectrometry. The data on outdoor CO was sourced from the China High Air Pollution dataset. Results. A total of 3,121 children were included. CO exposure was positively correlated with changes in systolic BP (β = 1.67; 95%CI: 0.80, 2.53; P = 0.001) and diastolic BP (β = 0.96; 95%CI: 0.26, 1.66; P = 0.007). Phosphatidylethanolamine (PE) (P-18:0/22:5) and triglyceride (TG) (17:1_17:1_13:0) may play a mediating role between CO and systolic BP changes, while lysophosphatidylcholine (LPC) (22:0), phosphatidylcholine (PC) (38:6), PC(O-21:2), phosphatidylserine (PS) (18:0/20:4), and sphingomyelin (SM) (d21:1) may mediate the relationship between CO and diastolic BP changes. The enrichment analysis indicated that CO exposure may primarily affect lipid metabolites related to acetylcholine synthesis, phospholipid biosynthesis, and phosphatidylcholine catabolism. Conclusion. CO exposure is positively correlated with changes in both systolic and diastolic BP in children. Additionally, lipid metabolites partly mediate the relationship between CO and changes in BP.

Source: Environmental Research Communications

DOI: 10.1088/2515-7620/ade1ac