The relationship between some immunological and biochemical parameters with COVID-19: A comprehensive review
Year: 2024
Type: article
Abstract: Coronaviruses, a family of RNA viruses, are known to infect various species, including humans, through specific receptors in organs such as the lungs and heart. The article highlights the significant elevation of biomarkers like C-reactive protein (CRP), ferritin, D-dimer, and lactate dehydrogenase (LDH) in COVID-19 patients, which correlate with disease severity and inflammatory responses and provides a comprehensive analysis of the immunological and biochemical factors associated with COVID-19, focusing on the role of coronaviruses. The authors discuss the zoonotic origins of SARS-CoV-2, tracing its transmission from bats to humans via intermediate hosts like pangolins. They emphasize the airborne nature of SARS-CoV-2 transmission among humans, primarily through respiratory droplets and potential fecal-oral routes. The structural characteristics of coronaviruses are examined, detailing their large size and spike proteins that facilitate entry into host cells by binding to the ACE2 receptor. The study emphasizes identifying reliable COVID-19 biomarkers, particularly C-reactive protein (CRP), for early diagnosis and severity assessment. It calls for continued research to improve diagnostic and therapeutic strategies in managing this viral infection.
Institution: Middle Technical University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411062004