Work

Targeting apoptotic pathways in cancer: design, synthesis, and molecular docking studies of 1,3,5-trisubstituted-1 H -pyrazole derivatives with Bcl-2 inhibition and DNA damage potential

Year: 2025

Type: article

Abstract: -pyrazole derivatives effectively target Bcl-2, activate apoptotic pathways, and induce DNA damage, making them promising candidates for further anticancer investigation.

Source: RSC Advances

DOI: 10.1039/d5ra02046h

Authors: Ahmed Temirak, Ahmed A. F. Soliman, Mohamed B. Shalaby, Mariam G. Eshak, Wagdy K. B. Khalil, Zahid Shafiq, Nader M. Boshta

Institutions: National Research Centre, General Organization For Teaching Hospitals and Institutes, Ministry of Health and Population, Bahauddin Zakariya University, Menoufia University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Research Centre, Menofia University

OpenAlex ID: W4411093044

FWCI: 1.069

Cites: 29

Cited by: 4

Related to: 10