Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Since 2022, Mpox has emerged among men who have sex with men (MSM) in Taiwan. Data on local risk factors remain limited, particularly the role of sexual behavior and STI history. METHODS: We conducted a retrospective case-control study at a regional hospital in Taoyuan from 2022 to 2024. MSM aged ≥18 years with at least one STI were included. Mpox cases were compared to STI-only controls. Data on demographics, HIV status, and behaviors were analyzed using Firth logistic regression. RESULTS: Among 729 MSM, 42 had confirmed Mpox. Having more than two prior STIs was strongly associated with Mpox (aOR = 17.32; 95 % CI: 5.64-53.17). In contrast, HIV viral load >1000 copies/mL (aOR = 0.02) and multiple sexual partners (aOR = 0.22) were linked to lower odds of infection. CONCLUSIONS: Multiple STIs were a strong predictor of Mpox. Lower infection rates among viremic or sexually active individuals may reflect behavior change or healthcare engagement. STI history may help guide targeted Mpox prevention.
Authors: Wei-Yen Chen, Shu-Hsing Cheng, Cheng-Pin Chen, Shu-Yuan Lee, Shin-Yen Ku, Shu-Ting Gan, Chen-En Hsieh, Chien-Yu Cheng
Language: English
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,650
OpenAlex ID: W4411166115