Year: 2025
Type: review
Abstract: Among the pervasive transcripts from eukaryotic genomes, a novel subset, referred to as architectural RNAs (arcRNAs), has an essential role in assembling membraneless organelles (MLOs). These arcRNAs sequester specific RNA-binding proteins (RBPs) and promote phase separation through multivalent interactions. NEAT1_2, an archetypal arcRNA, serves as a blueprint for paraspeckle architecture, characterized by a shell-and-core micelle-like configuration and immiscibility with other MLOs, relying on the cooperative contributions of distinct modular RNA domains. arcRNAs regulate gene expression through three of MLO action modes (crucible, sponge, and hub), guided by the functional blueprints embedded in arcRNA sequences. Advanced high-throughput analyses have identified thousands of arcRNA candidates, underscoring their potential in organizing transient intracellular compartments and driving dynamic cellular processes.
Source: Trends in Genetics
Authors: Tetsuro Hirose, Naoko Fujiwara, Kensuke Ninomiya, Tetsuya Yamamoto, Shinichi Nakagawa, Tomohiro Yamazaki
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Awards: G1983922210, Analysis of multifaced functions of repeat RNAs, G2576085165, Mechanism of Intracellular Spatial Compartmentalization Using the Self-Assembly Ability of RNA, G4337603245, G5348053622, G5947769297, G6718509927, G6747010605, 改良RNA抽出法で検出した新規RNAの転写開始点網羅的同定と細胞内機能解析, RNAによる非膜性構造体の形成と作動原理の確立, G9001073256
OpenAlex ID: W4411241249