Work

METTL5‐mediated 18S rRNA m6A modification enhances ribosome assembly and ABA response in Arabidopsis

Year: 2025

Type: article

Abstract: METTL5 catalyzes the N6-methyladenosine (m6A) methylation at A1771 in 18S rRNA, a modification essential for its association with the ribosomal protein RPL24A, facilitating the assembly of 80S ribosome. This facilitates the translation of mRNAs encoding the detoxifying glutathione S-transferase (GST) enzymes, thereby maintaining normal reactive oxygen species (ROS) levels and ensuring proper abscisic acid (ABA) responses. In mettl5 mutants, the absence of m6A1771 compromises RPL24A incorporation and ribosome assembly, impairing the translation of GSTs. This results in ROS excessive accumulation and hypersensitivity to ABA.

Source: iMeta

DOI: 10.1002/imt2.70055

Authors: Ping Li, Yu Zhang, Songyao Zhang, Jinqi Ma, Sheng Fan, Lisha Shen

Institutions: Temasek Life Sciences Laboratory, National University of Singapore

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,320