Predictive risk factors of recurrence in breast cancer after neoadjuvant treatment: the NEORISK study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Neoadjuvant chemotherapy (NACT) improves oncologic and cosmetic outcomes in breast cancer (BC), yet recurrence remains a concern. This study identifies factors associated with recurrence at 3 and 5 years in BC patients receiving NACT.Methods A retrospective analysis of 933 stage I – III BC patients (2014–2021) evaluated event-free survival (EFS) predictors using multivariate analyses.Results Lower 5-year EFS was linked to axillary staging (cN, p < 0.001), molecular subtype (p < 0.001), surgery type (p = 0.030), and post-surgical nodal status (ypN, p = 0.005). High recurrence risk was observed with aggressive tumor biology, advanced disease, and residual nodal burden, while favorable responses correlated with better outcomes.Conclusion Biological and clinical factors guide post-NACT strategies to reduce recurrence in high-risk BC patients.
Source: Future Oncology
Authors: Franco Antonio, Luisa Carbognin, Ida Paris, Alba Di Leone, Armando Orlandi, Fabio Marazzi, Antonino Mule, Paolo Belli, Alessandro Rossi, Stefano Magno, Antonella Palazzo, Valeria Masiello, Angela Santoro, Paola Fuso, Emilio Bria, Sabatino D’Archi, Lorenzo Scardina, Alejandro Martin Sanchez, Diana Giannarelli, Stefano Paternello, Giorgia Garganese, Giovanni Scambia, Giampaolo Tortora, Riccardo Masetti, Gianluca Franceschini, Alessandra Fabi
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Funder: Ministero della Salute
Award: G1732041760
OpenAlex ID: W4411298677