A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment
Year: 2025
Type: article
Abstract: exploration of different drug administration scenarios. It can provide valuable support for optimizing dose and schedule and allows the efficient investigation of drug distribution at a whole-body scale. This approach promises to enhance the personalization and effectiveness of cancer therapies, reduce research time and costs, and significantly advance the development of mRNA-based BiTEs for cancer treatment.
Authors: Giada Fiandaca, Elio Campanile, Lorena Leonardelli, Elisa Pettinà, Stefano Giampiccolo, Elizabeth J. Carstens, Lorenzo Dasti, Natascia Zangani, Luca Marchetti
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funder: Wellcome Leap
OpenAlex ID: W4411334621