346 | Rituximab‐dose‐adjusted Epoch Versus Rituximab‐chop in Primary Mediastinal Large B‐cell Lymphoma
Year: 2025
Type: article
Abstract: mFU of 52 months (5-178) from relapse, 4-year PFS and OS were 37% and 66%, respectively.At first relapse, 30 patients (35%) received autologous stem cell transplantation (ASCT) as consolidation therapy, with a 4-year PFS from ASCT of 76%.36 patients (42%) received CAR-T cell therapy in second or subsequent treatment lines.Of them, 20 patients (56%) achieved prolonged CR, after a mFU from CAR-T infusion of 25 months (5-72) in CR patients.In 24 patients (28%) a checkpoint inhibitor (50% monotherapy) was used as salvage treatment in second or subsequent treatment lines.Five (29%) patients reached sustained CR (mFU of 11 months) without CAR-T or transplant consolidation.Conclusions: Our results indicate that DA-EPOCH-R has significantly higher efficacy than R-CHOP-21 with lower use of RT.The prognosis is good for most patients, even R/R patients seem to have better prognosis than reported in historical series, probably related to new treatment approaches.
Source: Hematological Oncology
Authors: T. Vassilakopoulos, Z. Mellios, G. Papageorgiou, A. Piperidou, E. Verigou, C. Chatzidimitriou, C. Kalpadakis, E. Katodritou, H. Giatra, V. Xanthopoulos, G. Gainaru, E. Vrakidou, T. Leonidopoulou, M. Kotsopoulou, M. Palassopoulou, S. Karakatsanis, M. Tsirogianni, E. Hatzimichael, E. Terpos, P. Zikos, C. Poziopoulos, E. Vervessou, M. Arapaki, A. Kopsaftopoulou, A. Liaskas, P. Katsaouni, J. Assimakopoulos, G. Kourti, D. Koutsiafes, M. Siakantaris, G. Karianakis, A. Symeonidis, D. Grentzelias, V. Pappa, P. Tsirigotis, E. Papadaki, E. Plata, M. Bakiri, G. Pangalis, M. Angelopoulou, M. Bouzani
Institutions: Laiko General Hospital of Athens, Evangelismos Hospital, University of Patras, University of Crete, University Hospital of Heraklion, Theageneio General Hospital, Hygeia Hospital, Sismanoglio General Hospital, Metaxa Hospital, University of Thessaly, University Hospital of Larissa, National and Kapodistrian University of Athens, Sotiria General Hospital, St Savas Hospital, University of Ioannina, Alexandra Hospital, Agios Andreas Hospital, Metropolitan Hospital, Henry Dunant Hospital
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411384656