Review of Angiotensin-converting Enzyme and Alpha-Actinin-3 Polymorphism Impact in Individual and Team Sports
Year: 2025
Type: article
Abstract: BackgroundThe effect of the biological and genetic background of an individual on success in sports is a generally accepted fact with a multifactorial background.Research data show that life habits, such as diet and sleep, are extremely important for recovery from intense training and physical activity.1 The influence of genetics is also often mentioned, especially because of family traditions in certain sports. 2 Through advancements in technology and science, single nucleotide polymorphisms and other genetic variants that could influence sports performance have been identified.New studies have associated 251 deoxyribonucleic acid (DNA) polymorphisms, some of the highly relevant genetic markers being HFE rs1799945 C>G, T; MYBPC3 rs1052373 C>T; AMPD1 rs17602729 G>A, T; LRPPRC rs10186876 A>G, T; and MMS22L rs9320823 T>A, C. 3 Numerous research studies show an association between two genes, angiotensin I-converting enzyme (ACE) and α-actinin-3 (ACTN3), with sports performance, more specifically, ACE insertion/deletion polymorphism of a 287 bp Alu sequence in intron 16 of the gene (ACE I/D rs1799752) and
Source: Science, Art and Religion.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4411520366