Year: 2021
Type: article
Study design: Case Report
Abstract: A 27-year-old male with isolated recurrence of Myeloid sarcoma (MS) of the brain 8 months post successful treatment of acute myeloid leukemia (AML).Magnetic resonance images (MRI) and Computed tomography (CT) scans suggest altered signal intensity lesion in the sigmoid sinus right side infiltrating the cerebellar hemisphere with perilesional edema.Cerebrospinal fluid (CSF) cytology showed positive for malignant cells, involvement by AML is suggested.There was no relapse in the bone marrow.He has been treated with whole-brain radiation (24 Gy in 12 fractions) along with twice-weekly triple intrathecal injections consisting of cytarabine (70 mg), methotrexate (12 mg), and prednisolone (50 mg).After five courses of injections with intrathecal cytarabine, prednisolone, and methotrexate, CSF cytology of three consecutive times showed negative for malignancy.Furthermore, he was scheduled for systemic chemotherapy with cytarabine 3 gm/m2 twice daily for three consecutive days.He has been in complete remission.Our findings, together with other reported cases, suggest that a favorable outcome could be achieved by intensive and combined treatment for an isolated relapse of myeloid sarcoma (MS) of the brain if the bone marrow persisted in remission.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411577618