An exciting future for microbial molecular biology and physiology
Year: 2025
Type: review
Abstract: Continuous advances in technologies ranging from deep sequencing and genetic manipulation to mass spectrometry, single cell imaging, and structural biology have led to previously unimaginable advances in our understanding of microbial physiology and the molecular mechanisms underlying microbial responses in a multitude of environments. Simultaneously, these advances are revealing how much more there is to learn. At the 2024 virtual retreat of the Molecular Biology and Physiology (MBP) Community of the Council on Microbial Sciences (COMS) of the American Society for Microbiology (ASM), eight early-career investigators, along with retreat attendees, discussed some of these astounding advances, as well as the challenges and opportunities the developments raise. Motivated by these discussions, we review the state-of-the-art in molecular microbiology and provide an outlook on this field. Our hope is that the topics discussed here can serve as an inspiration for the development of future technologies, resources, and guidelines and for the training of the next generation of microbiologists.
Source: mBio
Institutions: Carnegie Mellon University, University of Nebraska Medical Center, St. Jude Children's Research Hospital, University of Washington, The University of Texas Health Science Center at Houston, Stanford University, University of Rochester Medicine, University of Rochester, University of Massachusetts Chan Medical School, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rutgers, The State University of New Jersey, University of South Florida
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funders: University of South Florida, Charles E. Kaufman Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Treatment of Multidrug-Resistant Staphylococcus aureus Orthopaedic-Device Related Biofilm Infections with Local Delivery of Lytic Bacteriophage, G2528943665, Small ORFs, Evolution of bacterial communication systems, Small, Noncoding RNAs, G5490544624, G5856021004, A universal pipeline for functional characterization of the human microbiota at a massive scale, G7285154571, This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersal, G7902122540, G9000162936, Investigating the molecules and mechanisms of bacterial cell-cell interactions, Structural Basis of Programmable DNA-Insertion via Cryo-EM Studies of CRISPR-Associated TnsC, Harnessing Broad-Specificity Phage Recombinases for Universal Bacterial Editing platforms, Developing a single cell resolution understanding of pathogenesis and antibiotic tolerance in Staphylococcus aureus
OpenAlex ID: W4411784111