Treatment approaches of hypertriglyceridemia in patients with dyslipidemia and obesity
Year: 2025
Type: article
Abstract: The high prevalence of obesity and its associated cardiovascular diseases ( CVD) constitutes a significant medical and social concern. Dyslipidemia is one of the principal risk factors in this patient cohort. Notably, beyond elevated low-density lipoprotein cholesterol (LDL-C) — the primary atherogenic factor — dyslipidemia in obese patients is typically characterized by increased serum triglyceride (TG) levels and reduced high-density lipoprotein cholesterol ( HDL-C) fractions, both of which contribute to the residual risk of CVD even after LDL-C correction. Therefore, the management of dyslipidemia in obese individuals requires a comprehensive approach, including both non-pharmacological interventions and pharmacotherapy. According to clinical guidelines, statins represent the first- line drug therapy; however, available data indicate that these agents have only a modest effect on hypertriglyceridemia. Consequently, patients with obesity commonly require combination therapy, with the addition of fibrates and/or omega-3 polyunsaturated fatty acids (omega-3 PUFAs) to statins. Among fibrates, fenofibrate is the only agent recommended for concomitant use with statins. Its micronized formulation enhances bioavailability, thereby increasing its hypolipidemic efficacy and improving patient compliance. When adding omega-3 PUFAs, the use of pharmaceutical-grade preparations is advised. Both agents, according to several studies, significantly reduce TG levels, while fenofibrate also increases HDL-C concentrations, thus contributing to the prevention of cardiovascular complications in obese patients’.HDL, contributing to the prevention of cardiovascular complications in obese patients. Keywords: dyslipidemia, obesity, hypertriglyceridemia, fenofibrate, omega-3 polyunsaturated fatty acids. For citation: Ostroumova O.D., Telkova S.S., Dubinina A.V., Ebzeeva E.Yu., Klepikova M.V., Arablinsky A.V., Doldo N.M. Treatment approaches of hypertriglyceridemia in patients with dyslipidemia and obesity. RMJ. 2025;5:29–35. DOI: 10.32364/2225-2282-2025-5-6
Source: Русский медицинский журнал
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412095973