Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction Dissemination indices derived from [18F]FDG PET/CT, such as Dmax, Dmaxbulk, SPREADbulk, SPREADpatient, and DmaxVox are validated prognostic biomarkers in diffuse large B-cell lymphoma. We introduce DmaxVoxMIP, the distance between the outermost voxels of the two most distant lesions on a 2D maximum intensity projection image, which is easy and straightforward to obtain. Our goal is to evaluate DmaxVoxMIP’s prognostic value compared to other features for easier clinical application. Methods Metabolic tumor volume and dissemination indices were obtained from LIFEx, while DmaxVoxMIP was obtained from Telemis and OsiriX. Results DmaxVoxMIP was not significantly higher in deceased than in living patients. However, patients with DmaxVoxMIP values above the derived cutoff showed a shorter survival. By combining MTV and DmaxVoxMIP, we obtained 3 risk groups for OS and PFS. Discussion DmaxVoxMIP could advantageously replace other dissemination parameters as a prognostic index in patients with DLBCL.
Source: Frontiers in Medicine
Authors: Isaac Kargar Samani, Olivier Gheysens, Maxime Regnier, Alix Collard, Marc André, Eric Van Den Neste, Thierry Vander Borght
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4412379719