Study of the role of serum cellular communication network 3 level in the pathogenesis and severity of psoriasis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Psoriasis is a chronic immune-mediated inflammatory condition of the skin. The definite etiology of psoriasis is still not fully elucidated. Members of the cellular communication network (CCN) family of matricellular proteins include CCN1 –6. The only available data connecting CCN proteins to psoriasis is concerning CCN1, which was reported to be up-regulated in psoriatic skin lesions, indicating its role in the pathogenesis of psoriasis. Recently, CCN3 was suggested to play a crucial role in the development of some inflammatory and autoimmune diseases. Aims To investigate serum level of CCN3 in psoriatic patients in comparison to healthy patients, and to assess its possible association with disease severity. Patients and methods This is an observational case–control study that investigated 48 adult patients with psoriasis and 48 healthy individuals matching in age and sex as a control group. Psoriasis patients were clinically and laboratory assessed and disease severity was assessed by psoriasis area and severity index score. Serum CCN3 level was assessed for patients and controls using the ELISA technique. Results A statistically significant higher serum level of CCN3 was detected in psoriasis patients in comparison with controls ( P =0.002). No significant correlation was detected between serum CCN3 levels and either patient’s age, C-reactive protein level, lipid profile parameters, disease duration or disease severity. Conclusions Elevated serum CCN3 levels in psoriasis patients might indicate its possible role in the disease pathogenesis. Therefore, it could be proposed that CCN3 shares other members of the CCN family of proteins as a role-player in psoriasis inflammatory disease cascades.
Source: Tanta Medical Journal
Institution: Tanta University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4412409254