Surveillance and follow up outcomes of myocarditis after mRNA COVID-19 vaccination in Australia
Year: 2025
Type: article
Study design: Observational Study
Abstract: Clinical progression and medium-long term morbidity from myocarditis following mRNA COVID-19 vaccinations remains an important but undefined public health concern. We conducted prospective follow-up of individuals with either confirmed or probable myocarditis following monovalent Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccination between 21 April 2021 and 5 July 2022 in Australia. Of 256 individuals who consented to follow up, mostly males following a second dose, 60% (133/221) had ongoing symptoms at 3-6 months and 35% (81/231) at 12-18 months. Self-reported ongoing exercise restrictions, medication requirements, and hospital re-presentations were associated with ongoing symptoms, as was a lower self-reported health status and quality of life. Clinical severity remained mild, with low hospitalisation rates and no deaths in the follow-up period and health-related quality of life improved over time. These findings support ongoing use of mRNA COVID-19 vaccines in at-risk individuals to prevent disease caused by SARS-CoV-2 infection.
Source: npj Vaccines
Authors: Lucy Deng, Amanda Van Eldik, Megan O’Moore, Jim Buttery, Abigail Cheung, Nicholas Cox, Carla Drake-Brockman, Nathan Dwyer, Paul Effler, Michael Gold, Pravin Hissaria, Andrew Kelly, Sarah Khanlari, Claire Larter, Shannon Melody, Michael Nissen, Rajesh Puranik, James Rankin, Sally Singleton, Liza Thomas, Sudhir Wahi, Gavin Wheaton, Dominica Zentner, Kristine Macartney, Clara K. Chow, Nicholas Wood
Institutions: The University of Sydney, Children's Hospital at Westmead, Sydney Children's Hospital, Department of Health and Aged Care, The University of Melbourne, Murdoch Children's Research Institute, Women's and Children's Health Network, The Royal Melbourne Hospital, Western Health, Princess Margaret Hospital for Children, Perth Children's Hospital, Royal Hobart Hospital, Government of Western Australia Department of Health, Adelaide University, The University of Adelaide, South Australia Pathology, New South Wales Department of Health, Tasmanian Department of Health, Prince Charles Hospital, Royal Prince Alfred Hospital, Fiona Stanley Hospital, ACT Government, Westmead Hospital, Princess Alexandra Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
OpenAlex ID: W4412464697