Work

Association of obesity with metastatic bone disease in prostate cancer: a case-control study

Year: 2025

Type: article

Abstract: Background: This study aimed to determine the relationship between obesity and the risk of bone metastases in prostate cancer patients by analyzing clinical and anthropometric variables.Methods: A case-control study was conducted at the Nuclear Medicine Department of the University Hospital José Eleuterio González from May to October 2024.A total of 85 adult prostate cancer patients were included: 28 cases (with bone metastases) and 57 controls.Body mass index, body fat percentage, and other clinical parameters were evaluated.Results: Obesity, as determined by BMI at the time of bone scintigraphy, showed an inverse association with bone metastases (odds ratio 0.89; 95% CI: 0.123-0.76;p < 0.05), suggesting a potential protective effect.No significant association was observed between initial BMI or body fat percentage and metastases.Body fat percentage classified more patients as obese (71.43%) than BMI (33.33%) (p < 0.0001).Conclusions: Obesity based on BMI at the time of bone scintigraphy may have a protective role against bone metastases in prostate cancer.Findings emphasize the need to evaluate body composition in clinical management.

Source: Medicina Universitaria

DOI: 10.24875/rmu.24000051