Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting
Year: 2025
Type: review
Abstract: Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist therapies. Beyond producing energy and building blocks to meet cancer cell demands, glucose metabolism generates numerous metabolites that serve as signaling molecules, orchestrating signaling pathways and epigenetic modifications that regulate cancer cell phenotypes and immunity. In this review, we discuss how glucose, through its metabolism and direct actions, influences diverse biological processes driving cancer progression and therapeutic resistance, while also exploring metabolic vulnerabilities in cancer for therapeutic strategies.
Source: Journal of Biomedical Science
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
Awards: Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer, Unravel a novel metabolic pathway orchestrating prostate cancer progression and therapeutic resistance, Drug Development of Skp2 PROTACs in Cancer, Identification of a novel targetable cancer stem cell regulator promoting cancer progression and metastasis in non-small cell lung cancer
OpenAlex ID: W4412784686