Work

Synthesis and anticancer activity of cyclometalated Pt( ii ) neutral complexes containing curcumin as a bioactive ancillary ligand

Year: 2025

Type: article

Abstract: values of 15.4 μM and 13.9 μM, respectively. These compounds maintained significant activity over 72 h, aligning with their spectroscopic stability. Given their potency, selectivity and lack of photoactivation requirement, complexes 4 and 5 emerged as promising candidates for the treatment of Ewing's sarcoma.

Source: Dalton Transactions

DOI: 10.1039/d5dt01323b

Authors: Eugenia Giorno, Giorgio Facchetti, Nicolas Godbert, Giuseppe Di Maio, Massimo La Deda, Giulia Coffetti, Isabella Rimoldi, Valentina Coccè, Luisa Doneda, Giulio Alessandri, Francesca Paino, Augusto Pessina, Iolinda Aiello

Institutions: National Interuniversity Consortium of Materials Science and Technology, University of Calabria, University of Milan, Istituto di Nanotecnologia

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Università degli Studi di Milano, Ministero dell’Istruzione, dell’Università e della Ricerca, Ministero dell'Università e della Ricerca

Awards: G1079816887, G1540886192, G2484832597, G2720398104, G5658354198, G5829866654

OpenAlex ID: W4412823374

FWCI: 0.363

Cites: 60

Cited by: 1

Related to: 10