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Efficacy of Antibody-Drug Conjugates as a Potential Treatment for Patients with Colorectal Cancer: A Systematic Review and Meta-Analysis of Clinical Trials

Year: 2025
Type: review
Abstract: Purpose: Colorectal cancer is the third most common malignancy worldwide and a major cause of cancer-related deaths. Conventional therapies often fail to eliminate enough tumor cells without excessive toxicity. Antibody-drug conjugates (ADCs) leverage antibody specificity and potent cytotoxic agents, improving precision and reducing healthy tissue damage. This review assesses ADC efficacy and safety in colorectal cancer.
DOI: 10.1016/j.ajt.2025.07.1865
Authors: M. Khan, A. Bahr, B. Ahmed, H. Hamdar, M. Kakarla, A. Jlambo, A. Amer, T.A. Malik
Institutions: Mayo Clinic Hospital, Alexandria University, Tanta University, Centre Hospitalier Universitaire Notre Dame des Secours, Zagazig University, Mayo Clinic in Arizona
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412865613
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