Work

Characterizing the Urinary Microbiome in Renal Transplant Patients with Significant BK Polyomavirus (BKPyV) Reactivation

Year: 2025

Type: article

Abstract: Purpose: Significant BK polyomavirus (BKPyV) reactivation defined as BKPyV-DNAemia >10000 c/mL is a consequential health risk among renal transplant recipients that can lead to nephropathy and allograft loss. The microbiota is increasingly recognized for its roles in promoting or suppressing viral infection and pathogenesis, as well as undergoing compositional changes in response to infection, making it a potentially useful diagnostic tool. Exploring the urinary microbiome may progress our understanding of significant BKPyV reactivation and yield novel microbial biomarkers linked to disease pathology.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.1415

Authors: R. Nog, K.A. Bates, V.B. Rivera, T. Diflo, D. Glicklich, V. Chaturvedi

Institutions: Westchester Medical Center, Queen Mary University of London, Blizard Institute

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300