Assessment of De Novo Extended-Release Tacrolimus Weight-Based Dosing Compared to Immediate-Release Tacrolimus in Kidney Transplant Recipients Leads to Improved Outcomes
Year: 2025
Type: article
Abstract: Purpose: Tacrolimus is commonly utilized as maintenance immunosuppression in solid organ transplant recipients. Tacrolimus has a narrow therapeutic index and exhibits pharmacokinetic and pharmacodynamic variability. Dosing strategies remain inconsistent due to various formulations, desire to minimize renal vasoconstrictive effects, to avoid delayed graft function, and limit rejection. Tacrolimus XR uses MeltDose technology, improving bioavailability. This formulation provides rapid attainment of therapeutic levels with less fluctuation.
Authors: J. Quenzer, K. Chavin, K. Ly, I. Shah, C. Ruggia-Check, J. Au, A. Diamond
Institutions: Temple University Hospital, Temple University
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412866017