Chemotherapy-induced ileus and gastrointestinal hemorrhage following therapy with BrECADD for Hodgkin lymphoma: A case report
Year: 2025
Type: article
Study design: Case Report
Abstract: A 62-year-old male with newly diagnosed advanced-stage Hodgkin lymphoma (HL) developed life-threatening gastrointestinal (GI) complications during brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone chemotherapy. He presented with chemotherapy-induced enteritis and jejunal ileus, followed by severe GI bleeding requiring two consecutive laparotomies and segmental jejunal resections. Histology revealed ulcerative jejunitis without signs of lymphoma infiltration. His medical course was further complicated by acute renal failure requiring dialysis. Although the patient temporarily stabilized with intensive care management, he subsequently developed Candida sepsis. At the time of submission, his outcome remains uncertain. This case underscores a rare but serious occurrence of GI toxicity associated with intensive chemotherapy for HL.
Source: Tumor Discovery
DOI: 10.36922/td025180033
Authors: Karl Mayrhofer, Simon Udovica
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412920293