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Treatment of Refractory Grover’s Disease With Dupilumab: A Case Study

Year: 2025

Type: article

Abstract: Grover's disease (GD) is a pruritic skin condition characterized by erythematous, scaly papules on the trunk, often resolving spontaneously but sometimes becoming persistent and difficult to manage. In this case study, we discuss a 73-year-old male with treatment-resistant GD who experienced significant improvement with dupilumab injections. Within two weeks, the patient reported noticeable improvement in pruritus and rash, with complete resolution achieved after five months of continued treatment and no notable adverse effects. This case can highlight dupilumab as a promising option for refractory GD, as well as support the hypothesis of an immune-mediated pathogenesis of GD.

Source: Cureus

DOI: 10.7759/cureus.88695

Authors: Maclaine McCarter, David Cleaver, Jordan Lane

Institutions: A.T. Still University, Unity Health System, Community Health Systems - Northeast Regional Medical Center

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412927491