Work

Neuroinflammation, Nuclear Factor kappa B and Memory Impairment Induced by Lipopolysaccharides

Year: 2025

Type: article

Abstract: The transcription factor Nuclear Factor kappa B (NF-κB) controls several cellular signaling pathways, including inflammatory ones. In mammals, Gram-negative bacteria's cell wall contains a chemical called lipopolysaccharide (LPS), which is commonly used to induce inflammation of the nervous system. LPS can trigger NF-κB, Leading to an inflammatory response. This stimulation is part of the body's defense mechanism, incontrast to bacterial infection, but can also contribute to chronic inflammation if not regulated. So, LPS increases the expression of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor (TNF-α) via attaching to immune cells, as aresult of stimulating NF κB. Following the production of cytokines, the central nervous system (CNS)'s microglia and macrophages also generate these cytokines, which guide neuronal substrates and cause inflammation inside neurons. In addition to increasing amyloid precursor protein (APP) expression and the production of amyloid plaques, which cause Alzheimer's disease, these cytokines can also increase β-secretase mRNA, protein, and enzymatic activity.

Source: Aswan Science and Technology Bulletin

DOI: 10.21608/astb.2025.385925.1023

Authors: Ola A Mohamed, Eatemad Awadalla, Ahmed Abdelsadik, Hoda S Sherkawy, Abd El-Kader M Abd El-Kader

Institution: Aswan University

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Aswan University