Synthetic Approaches to Imidazo[1,2‐a]indole,2,3‐dihydro‐ 1H ‐imidazo[1,2‐a]‐indoles and Benzo[4,5]imidazo[1,2‐a]indole Derivatives: A Comprehensive Review
Year: 2025
Type: article
Abstract: ABSTRACT Imidazo[1,2‐a]indoles, 2,3‐dihydro‐1H‐imidazo[1,2‐a]‐indoles and benzo[4,5]imidazo[1,2‐a]indoles are rare yet valuable classes of nitrogen‐containing heterocycles, offering diverse applications in pharmaceutical development and advanced materials research. Despite their potential medicinal applications, efficient synthesis methods for these substances remain limited. This review provides an in‐depth analysis of emerging synthetic approaches for imidazo[1,2‐a]indoles and benzo[4,5]imidazo[1,2‐a]indoles, including metal‐catalyzed and metal‐free methods, as well as metal‐catalyzed synthesis of 2,3‐dihydro‐1H‐imidazo[1,2‐a]indoles, offering valuable insights into effective synthetic strategies.
DOI: 10.1002/jhet.70026
Authors: Elizabeth J. Diana, Thomas V. Mathew
Institution: Alphonsa College
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4413201850