Year: 2025
Type: preprint
Abstract: Recent work proposed that APOBEC-signature mutations in monkeypox virus (MPXV) are enriched in cruci-form structures formed by inverted repeats. We independently reanalyzed the same dataset with the published settings and several complementary approaches and found no statistically supported enrichment of mutations in these structures. While a modest trend at TC motif at 3’ end of hairpin loop contexts cannot be excluded, current evidence is insufficient. Additional data and careful handling of overlapping structures are needed to clarify any association.
Language: English
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funder: Russian Science Foundation
Award: G425487729
OpenAlex ID: W4413384635