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Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

Year: 2025
Type: review
Abstract: Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in disease pathogenesis remain largely unresolved. In this review, we summarize current advances in the regulatory interactions between lactylation and RNA modifications, explore their functional implications in cancer biology, and discuss the therapeutic potential of targeting these modifications individually or in combination. This work aims to provide a comprehensive overview of their mechanistic involvement in cancer and to inform novel strategies for precision-targeted therapy.
DOI: 10.1186/s40364-025-00824-9
Authors: Shantong Liu, Qianquan Ma, Chong Zeng, Haoyu Li, Jun Su, Zhihao Song, Ruyu Yan, Zijin Zhao, Songhai Tian, Wei Huang
Institutions: Central South University, Xiangya Hospital Central South University, Peking University, Peking University Third Hospital, University of South China, Hunan Children's Hospital, State Key Laboratory of Natural and Biomimetic Drugs
Language: English
Open Access status: gold
Estimated APC paid: $3,890
OpenAlex ID: W4413655799
FWCI: 1.678
Cites: 133
Cited by: 23
Related to: 10