Serum triglyceride and high-density lipoprotein at admission are associated with 30-day overall mortality of patients with HIV and talaromycosis
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Dyslipidemia is common in severe infections, but its role in patients with HIV and talaromycosis (PWHT) remains unclear. DESIGN AND METHODS: Three hundred and eighty-seven PWHT were enrolled in present study. Furthermore, 267 of 387 PWHT, 267 people with HIV but without talaromycosis (PWH), and 267 healthy controls were selected to compare the lipid profiles by propensity score matching (PSM) method on sex, age, body mass index (BMI), comorbidities and hepatitis B virus (HBV) infection. RESULTS: PWHT showed significantly lower total cholesterol [2.9 (2.2-3.5) vs. 3.5 (2.9-4.0) vs. 4.6 (4.0-5.2) mmol/l, P < 0.001], LDL [1.5 (0.9-2.0) vs. 1.9 (1.5-2.4) vs. 2.5 (2.1-3.1) mmol/l, P < 0.001] and HDL [0.5 (0.3-0.7) vs. 0.7 (0.6-0.9) vs. 1.2 (1.0-1.4) mmol/l, P < 0.001], but higher triglycerides [1.6 (1.2-2.0) vs. 1.3 (1.0-1.7) vs. 1.2 (0.9-1.7) mmol/l, P < 0.001] than PWH and healthy controls at admission. Multivariate Cox analysis identified triglycerides at least 2 mmol/l [adjusted odds ratio (AOR) (95% confidential interval, CI): 2.5 (1.3-4.7), P = 0.005], HDL less than 0.3 mmol/l [AOR:2.7 (1.4-5.3), P = 0.004], age at least 35 years [AOR:3.2 (1.6-6.4), P = 0.001], BMI less than 18.0 kg/m 2 [AOR:2.0 (1.0-3.8), P = 0.036), WBC at least 5 × 10 9 /l [AOR:2.4 (1.3-4.6), P = 0.006], albumin less than 27 g/l [AOR: 2.7 (1.2-6.3), P = 0.018], and nonamphotericin B therapy [AOR: 2.2 (1.1-4.5), P = 0.028] as independent mortality risk factors. The 30-day overall mortality was higher in patients with triglycerides at least 2 mmol/l (24.0 vs. 7.6%, Log-rank P < 0.001) or HDL less than 0.3 mmol/l (27.1 vs. 6.5%, Log-rank P < 0.001) among PWHT. CONCLUSION: PWHT exhibited distinct dyslipidemia patterns from PWH and healthy control. Elevated triglycerides and reduced HDL independently predicted poor outcomes of PWHT.
Source: AIDS
Authors: Handan Zhao, Shasha Ye, Guanjing Lang, Danting Tang, Jiaying Qin, Xingguo Miao, Mengyan Wang, Minghan Zhou, Lingyun Wang, Feifei Su, Lijun Xu
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4413817836