Enantioselective Construction of Heteroatom Stereocenters via N -Heterocyclic Carbene Catalysis
Year: 2025
Type: article
Abstract: Heteroatom stereogenic centers not only widely exist in natural products, bioactive molecules, and other functional compounds, but are also of great significance to developing chiral catalysts and ligands in asymmetric synthesis.Although significant efforts have been devoted to constructing heteroatom stereocenters, only limited methods have been reported to date when compared to the construction of carbon stereocenters, and mainly rely on transition metal catalysis.Therefore, the rapid access to optically active noncarbon centers still remains a big obstacle.a N-heterocyclic carbene (NHC) asymmetric catalysis, one biomimetic organocatalysis, has been recognized to be a powerful tool for the rapid assembly of chiral complex molecular architectures.However, previous works have mainly focused on the construction of carbon stereocenters and only recently has it been realized that the enantioselective access to heteroatom stereocenters could be achieved via using NHCs as organocatalysts.Herein, we present a Review to highlight recent advances in asymmetric assembly of heteroatom stereocenters catalysed by NHCs.The aim of this Review is to provide an overview of this area and serve as a source for future investigations.
Source: CCS Chemistry
Institution: Wuhan Institute of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4413904792