RELAÇÃO ENTRE VACINAÇÃO CONTRA A INFLUENZA E DESFECHOS CARDIOVASCULARES NO BRASIL ENTRE 2009 e 2022: UM ESTUDO ECOLÓGICO
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Influenza is linked to cardiovascular risks, such as myocardial infarction (MI), due to systemic inflammation. In Brazil, influenza vaccination is universal, but its population-level impact on cardiovascular outcomes remains understudied. Methods: An ecological study using secondary data (2009-2022) from Brazil’s five regions. Statistical models (beta and linear) assessed the association between vaccine coverage (doses/100,000 inhabitants) and in-hospital mortality, costs, length of stay, and hospitalization rates for MI/revascularization. Results: No significant association was found between vaccine coverage and mortality (MI: β = 4.8×10⁻⁶; p = 0.613; revascularization: β = 9.5×10⁻⁶; p = 0.576), length of stay, or hospitalization rates. Temporal reductions in MI mortality were significant (β = -0.0325; p < 0.001), likely tied to clinical advancements. Discussion: The lack of association contrasts with clinical trials [4], suggesting contextual factors (regional disparities, care quality) modulate outcomes. Conclusion: Influenza vaccination did not directly impact the analyzed outcomes, but integrated policies addressing regional disparities are critical for cardiovascular health.
Source: Brazilian Medical Students
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414136256