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Assessing cerebral microvascular volumetric with high-resolution 4D cerebral blood volume MRI at 7 T

Year: 2025
Type: article
Abstract: Arterial pulsation is crucial for promoting neurofluid circulation. Most previous studies quantified pulsatility via blood velocity-based indices in large arteries. Here we propose an innovative method to quantify the microvascular volumetric pulsatility index (mvPI) across cortical layers and white matter (WM) using high-resolution four-dimensional (4D) vascular space occupancy (VASO) and arterial spin labeling (ASL) magnetic resonance imaging (MRI) at 7 T with simultaneous pulse recording. We assessed aging-related changes in mvPI in 11 young (28.4 ± 5.8 years) and 12 older (60.2 ± 6.8 years) participants and compared mvPI with large artery pulsatility assessed by 4D-flow MRI. mvPI peaked in the pial surface (0.18 ± 0.04). Deep WM mvPI was significantly higher in older participants (P = 0.006) than young ones. Deep WM mvPI correlated with large artery velocity PI (r = 0.56, P = 0.0099). We performed test-retest scans, non-parametric reliability test and simulations to demonstrate the reproducibility and accuracy of the method. In conclusion, our non-invasive method enables in vivo fine-grained measurement of mvPI, with implications for glymphatic function, aging and neurodegenerative diseases.
DOI: 10.1038/s44161-025-00722-1
Authors: Fanhua Guo, Chenyang Zhao, Qinyang Shou, Ning Jin, Kay Jann, Xingfeng Shao, Danny JJ Wang
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $12,690
Funders: U.S. Department of Health and Human Services, National Institutes of Health, Office of the Director, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Office of Diversity and Inclusion
Awards: G1138295660, BBB Permeability Imaging in CADASIL, Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID), Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population, G3388778004, G3396779930, G3482703943, Laminar Perfusion Imaging, NOVA PTX Coil for Ultrahigh Field Imaging, G4299418693, G4524973782, G7024700299, Multiband ASL for Neurodevelopment Study, G8235937348, Non-invasive MRI mapping of BBB water exchange rate and permeability, Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population, Characterization of neurovascular and neurometabolic coupling of the negative BOLD response in human
OpenAlex ID: W4414523945
FWCI: 3.433
Cites: 103
Cited by: 6
Related to: 10